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patient Case studies
HEPATIQ calculates quantitiative indices of liver disease thus providing a comprehensive view of the health of the liver. Shown below are serial HEPAVIEW™ images of the liver, spleen and bone marrow for 8 patients. Also shown are HEPATIQ differential graphs for the indices PHM, fLV, fSV and HAI.
CASE 1 - Alcoholic Hepatitis (death) 53 year old female presented with PHM 48 (H5). HAI -0.35 indicated marked alcoholic hepatitis activity. fSV of about 4 indicated portal hypertension. Patient died soon after hospital admission.
CASE 2 - Alcoholic Hepatitis (recovery) 60 year old male presented with PHM 67 (H4). HAI -0.3 indicated marked alcoholic hepatitis activity. Patient quit drinking alcohol and recovered to PHM 91 (H3) over 3 years. HAI improved from -0.30 (marked) to -0.12 (moderate).
CASE 3 - Cryptogenic cirrhosis 74 year old female presented as H2 cirrhotic.Over the next 4 years her PHM and fLV both decreased indicating progressive chronic liver disease. There was no indication of alcoholic hepatitis. She developed ascites and died while awaiting a transplant.
CASE 4 - Cirrhosis and HCC. 82 year old female presented as H2 cirrhotic. She was stable H2 for three years. Then she developed Hepatocellular Carcinoma (HCC) and was treated with RFA and Y90. Unfortunately, after the Y90 therapy she developed ascites and hepatic encephalopathy and subsequently died.
CASE 5 - Liver Transplant 65 year old female with decompensation (H4) received a transplant liver. PHM was near normal (H1) post transplant indicating restoration of liver function. Spleen volume fSV dropped indicating reduction of portal hypertension.
CASE 6 - Autoimmune Hepatitis 65 year old female presented with ascites and jaundice. PHM was 59 (H5). She was diagnosed with Autoimmune Chronic Active Hepatitis and treated with Prednisone/Imuran. PHM improved to 80 (H3) in a few months and eventually to 93 (H2).
CASE 7 - MASH Risk 61 year old female patient presented as normal (H0) with PHM 103 and fLV 7. She was on Prednisone and gaining weight. Liver volume increased from 7 to 11 over six years indicating risk of developing metabolic dysfunction-associated steatohepatitis (MASH). Liver function remained normal.
CASE 8 - F4 with portal hypertension 42 year old female presented as F4 cirrhosis by elastography. PHM was borderline stable for 3 years (H1). In the fourth year PHM dropped rapidly indicating risk of decompensation. Increasing fSV indicated portal hypertension. There was no indication of alcoholic hepatitis.
